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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 3 February 2020 Vol. No. 9; Issue No. 408
Publications

1. Acharya S, Dutta S, Bose K (2020). A distinct concerted mechanism of structural dynamics defines activity of human serine protease HtrA3. Biochemical Journal. 477: 407-429.

2. Panda S, Swamidas J, Chopra S, Mangaj A, Fogliata A, Kupelian P, Agarwal JP, Cozzi L (2020). Treatment planning comparison of volumetric modulated arc therapy employing a dual-layer stacked multi-leaf collimator and helical tomotherapy for cervix uteri. Radiation Oncology. 15(1):22.

3. Thota RS, Garg R, Ramkiran S, Divatia JV (2020). Onco-anaesthesiology as an emerging sub-speciality domain: Need of the hour! Indian Journal of Anaesthesia. 64(1): 69-71.

4. Gillessen S, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Chi KN, Clarke N, Davis ID, de Bono J, Drake CG, Duran I, Eeles R, Efstathiou E, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, Gleave M, Halabi S, Heidenreich A, Heinrich D, Higano CTS, Hofman MS, Hussain M, James N, Kanesvaran R, Kantoff P, Khauli RB, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Reiter RE, Roach M, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Small E, Smith M, Soule H, Sternberg CN, Steuber T, Suzuki H, Sweeney C, Sydes MR, Taplin ME, Tombal B, Türkeri L, van Oort I, Zapatero A, Omlin A (2020). Management of patients with advanced prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. European Urology.

Thesis
1. Anuja Lipsa. 2019. Genomic landscape of hereditary and early onset sporadic colorectal cancer. (HBNI No.: LIFE09201404015) (Guide: Rajiv Sarin).

Site of the Week

PeptideCutter predicts potential cleavage sites cleaved by proteases or chemicals in a given protein sequence. PeptideCutter returns the query sequence with the possible cleavage sites mapped on it and /or a table of cleavage site positions.

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Interesting Reads

Cuzick J, Sestak I, Forbes JF, Dowsett M, Cawthorn S, Mansel RE, Loibl S, Bonanni B, Evans DG, Howell A, IBIS-II investigators (2020). Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial. Lancet. 395(10218): 117-122.

Legends of Science
Rudolf Ludwig Carl Virchow Srinivasa Ramanujan

Ramanujan was an Indian mathematician. With almost no formal training in pure mathematics, he made substantial contributions to mathematical analysis, number theory, infinite series, and continued fractions, including solutions to mathematical problems then considered unsolvable. English mathematician G. H. Hardy at the University of Cambridge, England. Recognizing Ramanujan's work as extraordinary, Hardy arranged for him to travel to Cambridge. In his notes, Ramanujan had produced groundbreaking new theorems, including some that Hardy said had "defeated him and his colleagues completely in addition to rediscovering recently proven but highly advanced results. Ramanujan independently compiled nearly 3,900 results (mostly identities and equations) which were completely novel; his original and highly unconventional results, such as the Ramanujan prime, the Ramanujan theta function, partition formulae and mock theta functions. The year after his death, Nature listed Ramanujan among other distinguished scientists and mathematicians on a "Calendar of Scientific Pioneers" who had achieved eminence. In 2011, on the 125th anniversary of his birth, the Indian government declared that 22 December will be celebrated every year as National Mathematics Day.

Andreas Vesalius Meghnad Saha

Meghnad Saha was an Indian astrophysicist. He gained global prominence for his development of the Saha Ionization Equation. He used to describe chemical and physical conditions in stars. His work allowed astronomers to accurately relate the spectral classes of stars to their actual temperatures. He earned his Indian School Certificate from Dhaka College. He was also a student at the Presidency College, Kolkata; a professor at Allahabad University from 1923 to 1938, and thereafter a professor and Dean of the Faculty of Science at the University of Calcutta. He became Fellow of the Royal Society in 1927. He was president of the 21st session of the Indian Science Congress in 1934. Saha's study of the thermal ionization of elements led him to formulate what is known as the Saha equation. This equation is one of the basic tools for interpretation of the spectra of stars in astrophysics. Saha was nominated for the Nobel Prize in Physics for 1930. He was the Director at Indian Association for the Cultivation of Science during 1953-1956. The Saha Institute of Nuclear Physics, founded in 1943 in Kolkata, is named after him. Saha was nominated for the Nobel Prize in Physics for 1930. The Nobel Committee evaluated Saha's work. It was seen as a useful application, but not a "discovery." Thus he was not awarded the Prize. Saha was nominated again for the Prize in 1937 and 1940 and in 1939, 1951 and 1955. The Committee held to its previous decision and thus Saha was not awarded the prize.

Upcoming Events
The 3rd International Cancer Congress

06-07 March 2020

At Masala Cottage, Janakpur, Madhyamanchal, Nepal.

3rd Global Expo on Cancer and Oncology Research

16-17 April 2020

At Hotel ANA Crown Plaza Narita, 68 Horinouchi, Narita, Chiba 286-0107, Japan.

AACR Annual Meeting 2020

24-25 May 2020

At San Diego Convention Center, San Diego, California.

Do You Know?

In 1965, a variety of chemicals were shown to prevent cancer induced by chemicals by activating the detoxification system, competitively inhibiting the carcinogen, preventing initiation of carcinogenesis and other unknown mechanisms.

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Cancer News
Brain tumours manipulate neighbouring synapses

29 January 2020, Nature

The growth of a brain tumour can be affected by the activity of its neighbouring neurons. The finding that such tumours send signals that boost connections between these neurons reveals a pathway that drives cancer growth…

Psychedelic compound found in magic mushrooms may help with anxiety and depression in cancer patients

01 February 2020, Science Focus

A one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to improve the emotional wellbeing of cancer patients for up to five years, researchers at NYU Grossman School of Medicine have found…

Assessing 'stickiness' of tumor cells could improve cancer prognosis

03 February 2020, EurekAlert

A team of researchers led by the University of California San Diego has created a device that measures how "sticky" cancer cells are, which could improve prognostic evaluation of patient tumors. The device is built with a microfluidic chamber that sorts cells by their physical ability to adhere to their environment…

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